PT LE will only work with digidesign hardware (AMIII or digi001 etc.) You can run Pro Tools Free, without any hardware, but you will be limited to I believe 8 tracks. I use basically the same setup as you in my home, and I am able to run 24 track sessions just fine (with VERY limited number of plug-ins mind you). My setup is G3/350, 640MB, 30GB ATA dedicated audio drive. Good luck!