I go straight from my synth into Digi, and there is no variation. What I hear going in, comes out the same. My setup is probably simpler than yours though, pk. I have mikes(1&2), Midi(3&4), Guitars(5&6), Misc. tape machines, or whatever(7&8). Many times, I'm glad my setup is so simple. That may not help answer your question, but I don't think it's anything Digi...don't think it would matter to plug into 1&2. I would think that anytime you go through an external mixer, that there WILL be variations to tweak... But, that's not a technical answer, just a gut feeling. roy